APStracts (ISSN 1080-4757) Vol. 5, 1998

The American Physiological Society

• Increased expression of heat shock protein-70 protects a549 cells against hyperoxia.. Wong, Hector R., Ingrid Y. Menendez, Marnie A. Ryan, Alvin G. Denenberg, and Jonathan R. Wisp[acute]e. Division Of Critical Care Medicine and Division Of Pulmonary Biology, Children_s Hospital Medical Center, Cincinnati, Oh . Hector R. Wong, MD, Division of Critical Care Medicine-OSB5, Children_s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, Tel: (513)-636-4259; Fax: (513)-636-4267; email: wonghr@chmcc.org APStracts 5:0161L, 1998.
• Glutamylcysteine synthetase: mrna stabilization and independent subunit transcription by 4-hydroxy-2-nonenal. Liu, Rui-Ming, Lin Gao, Jinah Choi, and Henry Jay Forman. Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, CA 90033 APStracts 5:0162L, 1998.
• Refilling of caffeine-sensitive intracellular calcium stores in bovine airway smooth muscle cells. Madison, J. Mark, Michael F. Ethier, Hiroshi Yamaguchi. Departments of Medicine and Physiology, University of Massachusetts Medical School, Worcester, MA 01655 APStracts 5:0163L, 1998.
• Temporal, spatial, and oxygen-regulated expression of hypoxia -inducible factor 1 in the lung. Yu, Aimee Y., Maria G. Frid, Larissa A. Shimoda, Charles M. Wiener, Kurt Stenmark and Gregg L. Semenza. 1Institute of Genetic Medicine and 2Division of Pulmonary and Critical Care, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287; and 3Developmental Lung Biology Laboratory, University of Colorado Health Sciences Center, Denver, Colorado 80262 APStracts 5:0164L, 1998.
• Gia(2) is required for carbachol-induced stress fiber formation in human airway smooth muscle cells. Hirshman, Carol A., _ Hideaki Togashi, Dan Shao, and Charles W. Emala . Departments of Anesthesiology* and Environmental Health Sciences_ The Johns Hopkins Medical Institutions, Baltimore, MD APStracts 5:0165L, 1998.
• Sodium hydrosulfite-induced contractions of smooth muscle are calcium and myosin phosphorylation independent. Yu, Ming-Fu, Isabelle Gorenne, Xioaling Su, Robert S. Moreland, and Michael I. Kotlikoff. Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 and Department of Physiology, Graduate Hospital Research Building, Allegheny University of the Health Sciences, Philadelphia, PA 19146 APStracts 5:0166L, 1998.
• A1 adenosine receptor-mediated inositol 1,4,5-trisphosphate generation in allergic rabbit airway smooth muscle. Abebe, Worku, and S. Jamal Mustafa. Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC 27858 APStracts 5:0167L, 1998.
• Maternal exposure to environmental tobacco smoke alters clara cell secretory protein expression in fetal rat lung. Ji, Chun-Mei, Fred H. Royce_, Uyen Troung, Charles G. Plopper, Gurmukh Singh, and Kent E. Pinkerton. Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine*, and Department of Pediatrics_, School of Medicine, University of California, Davis, CA Department of Veterans Affairs Medical Center, University of Pittsburgh, Pittsburgh, PA APStracts 5:0168L, 1998.
• Flavonoids stimulate cl conductance of human airway epithelium in vitro and in vivo. Illek, Beate, and Horst Fischer. Children's Hospital Oakland, Research Institute, 747 Fifty Second Street, Oakland CA 94609, phone 510 428 3885 x 2496, fax 510 450 5839, email beate@socrates.berkeley.edu or hfischer@lanminds.com APStracts 5:0169L, 1998.
• Nitric oxide synthesis by tracheal smooth muscle cells by a nitric oxide synthase independent pathway. Jia, Yanlin, Mary Zacour, Barbara Tolloczko, and James G. Martin. Meakins-Christie Laboratories, McGill University and Cystic Fibrosis Laboratory, Montreal Chest Hospital, Montreal, Quebec, Canada H2X 2P2 APStracts 5:0170L, 1998.
• Shedding of l-selectin and pecam-1 and upregulation of mac-1 and icam-1 on neutrophils in rsv bronchiolitis. Wang, Shan-Ze, Peter K. Smith, Melanie Lovejoy, Jeffrey J. Bowden, John H. Alpers, Kevin D. Forsyth . Departments of Paediatrics and Respiratory Medicine , Flinders Medical Centre, Flinders University, SA 5042, Australia APStracts 5:0171L, 1998.
• Tgf-1 inhibits surfactant component expression and epithelial cell maturation in cultured human fetal lung. Beers, Michael F., Kola O. Solarin, Susan H. Guttentag, Joel Rosenbloom, Annapurna Kormilli, Linda W. Gonzales and Philip L. Ballard. 1 Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 2 Division of Neonatology, Department of Pediatrics, Allegheny University School of Medicine, Philadelphia, Pennsylvania, 3 Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 4 Department of Anatomy and Histology, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania APStracts 5:0172L, 1998.
• Endogenous pulmonary nitric oxide in the regulation of airway microvascular leak. Mehta, Sanjay, Jacques Boudreau, Craig M Lilly, and Jeffrey M Drazen. Pulmonary and Critical Care Division, Departments of Medicine, Brigham and Women_s Hospital, and Harvard Medical School, Boston, MA. APStracts 5:0173L, 1998.
• Induction of apoptosis by particulate matter: role of tumor necrosis factor-a and mitogen activated protein kinase. Chin, Beek Yoke, Mary E. Choi+, Marie D. Burdick#, Robert M. Strieter#, Terence H. Risbyand Augustine M.k. Choi, . Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT 06250** and CT VA HealthCare System, West Haven, CT 06516**, Section of Nephrology, Yale University School of Medicine, Department of Internal Medicine, New Haven, CT 06250+, and CT VA HealthCare System, West Haven, CT 06516+, Division of Pulmonary and Critical Care Medicine and Department of Environmental Health Sciences*, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, and Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109# APStracts 5:0174L, 1998.
• Clara cell secretory protein decreases lung inflammation following acute virus infection. Harrod, Kevin S., Amber D. Mounday, Barry R. Stripp, Jeffrey A. Whitsett. Children s Hospital Medical Center, Div. of Pulmonary Biology, Cincinnati, OH, 45229; *Dept. of Environmental Medicine, Univ. of Rochester, Rochester, NY. APStracts 5:0175L, 1998.
• Captopril inhibits apoptosis induced by fas in human lung epithelial cells: a potential antifibrotic mechanism. Uhal, Bruce D., Claudia Gidea, Raed Bargout, Antonio Bifero, Olivia Ibarra-Sunga, Michael Papp, Kevin Flynn, and Gerasimos Filippatos. The Cardiovascular Institute, Michael Reese Hospital and Medical Center, Chicago, IL, and 1Division of Cardiology, Evangelismos General Hospital, Athens, Greece. APStracts 5:0176L, 1998.
• The role of plasmalemmal caveolae in signal transduction. Anderson, Philip W. Shaul Richard G. W. Departments of Pediatrics1 and Cell Biology and Neuroscience2, University of Texas Southwestern Medical Center at Dallas APStracts 5:0177L, 1998.
• Cell size, cell cycle and alpha-smooth muscle actin expression by primary human lung fibroblasts. Uhal, Bruce D., Carlos Ramos, Iravati Joshi, Antonio Bifero, Annie Pardo, and Moises Selman. Lung Cell Kinetics Laboratory and The Cardiovascular Institute, Michael Reese Hospital, Chicago, Illinois; Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Mexico D.F., Mexico; Instituto Nacional de Enfermedades Respiratorias, Mexico, D.F., Mexico. APStracts 5:0178L, 1998.
• Changes in alveolar septal border lengths with postnatal lung growth. Wood, Jonathan P., John E. Kolassa, and John T. McBride. Departments of Pediatrics1 and Biostatistics2, University of Rochester, Rochester, New York, 14642 APStracts 5:0179L, 1998.
• Activation of human macrophages by mechanical ventilation in vitro. Pugin, J[acute]er[circumflex]ome, Ir[grave]ene Dunn, Philippe Jolliet, Didier Tassaux, Jean-Luc Magnenat, Laurent P. Nicod and Jean-Claude Chevrolet. Divisions of Medical Intensive Care and *Pulmonary Medicine, Department of Internal Medicine, University Hospital of Geneva, 1211 Geneva 14, Switzerland APStracts 5:0180L, 1998.
• Characterization of a csa-sensitive purine-box transcriptional regulator in human bronchial epithelial cells. Aoki, Yosuke, Guohua Zhao, Daoming Qiu, Lingfang Shi, and Peter N. Kao. Pulmonary and Critical Care Medicine, Stanford University Medical Center, Stanford, CA 94305-5236 APStracts 5:0181L, 1998.
• Maturational shift in the k+ channel regulating pulmonary artery membrane potential, from ca2+-sensitive to voltage-dependent. Reeve, Helen L., E. Kenneth Weir, Stephen L. Archer, David N. Cornfield. Departments of Medicine, Pediatrics2 and Physiology1, University of Minnesota, MN 55455 & VA Medical Center, Minneapolis, MN 55417 and Department of Medicine3, University of Alberta, Edmonton, Canada. APStracts 5:0182L, 1998.
• Differential regulation of baboon sp-a1 and sp-a2 genes; structural and functional analysis of 5_-flanking dna. Li, Jinxing, Erwei Gao, Steven R. Seidner and Carole R. Mendelson,. Departments of 1Biochemistry and 2Obstetrics-Gynecology, 3The Cecil H. & Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235-9038 and 4Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 -7812 APStracts 5:0183L, 1998.
• Regulation of alveolar macrophage and type ii cell dna synthesis. effects of ozone inhalation. Prokhorova, Svetlana, Naimish Patel, and Debra L. Laskin. Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854-8022 APStracts 5:0184L, 1998.
• Superoxide released from neutrophils causes a reduction in nitric oxide gas. Jones, Kimberly L., Ty W. Bryan, Patricia A. Jinkins, Keith L. Simpson, Matthew B. Grisham, Michael W. Owens, Shawn A. Milligan, Boaz A. Markewitz, Richard A. Robbins. Departments of Medicine and Physiology and Biophysics, Overton Brooks VA and LSU Medical Centers, Shreveport, LA APStracts 5:0185L, 1998.
• Effects of initial length on intrinsic tone in guinea-pig tracheal smooth muscle. Bard, Martin, Sergio Salmeron, Catherine Coirault, Francois-Xavier Blanc, Yves Lecarpentier. * Unit[acute]e de Pneumologie, Service de M[acute]edecine Interne, H[circumflex]opital Universitaire Bic[circumflex]etre, 94275 Le Kremlin-Bic[circumflex]etre, France, ** INSERM U451-LOA-ENSTA-Ecole Polytechnique, batterie de l'Yvette, 91125 Palaiseau. Service de Physiologie Cardio-Respiratoire, H[circumflex]opital Universitaire Bic[circumflex]etre, 94275 Le Kremlin-Bic[circumflex]etre, France. APStracts 5:0186L, 1998.
• Colocalization of alveolar epithelial cell death and underlying myofibroblasts in advanced fibrotic human lung. Uhal, Bruce D., Iravati Joshi, W. Frank Hughes, Carlos Ramos, Annie Pardo and Moises Selman. The Cardiovascular Institute, Michael Reese Hospital, 1Department of Anatomy, Rush Medical College, Chicago, Illinois, 3National Autonomous University of Mexico and the 2National Institute of Respiratory Diseases, Mexico D.F., Mexico. APStracts 5:0187L, 1998.
• Angiotensin iv receptor-mediated activation of endothelial no synthase is associated with pulmonary vasorelaxation. Patel, Jawaharlal M., Jeffrey R. Martens, Yong D. Li, Craig H. Gelband, Mohan K. Raizada and Edward R. Block,. Research Service1, Department of Veterans Affairs Medical Center, and the Departments of Medicine2 and Physiology3, University of Florida College of Medicine, Gainesville, FL APStracts 5:0188L, 1998.
• Time course of neutrophil and macrophage elastinolytic activities in cigarette smoke-induced emphysema.. Ofulue, A. Felix, Mary Ko, and Raja T. Abboud . DEPARTMENT OF MEDICINE, RESPIRATORY DIVISION, THE UNIVERSITY OF BRITISH COLUMBIA AND VANCOUVER GENERAL HOSPITAL, VANCOUVER, B. C., CANADA APStracts 5:0189L, 1998.
• Silica-induced chemokine expression in alveolar type ii cells is mediated by tnf-a. Barrett, Edward G., Carl Johnston, G[umlaut]unter Oberd[diaeresis]orster and Jacob N. Finkelstein,. Department of Environmental Medicine1 and Pediatrics2, University of Rochester School of Medicine, Rochester, New York 14642. APStracts 5:0190L, 1998.
• Exercise effects on ifn- expression and viral replication in lung macrophages following hsv-1 infection. Kohut, M. L., J. M. Davis, D. A. Jackson, P. Jani, A. Ghaffar, E. P. Mayer, D. A. Essig. Departments of Exercise Science, School of Public Health, and the Department of Microbiology/Immunology, School of Medicine, University of South Carolina, Columbia, SC 29208 APStracts 5:0191L, 1998.
• Equibiaxial deformation-induced injury of alveolar epithelial cells in vitro.. Tschumperlin, Daniel J., and Susan S. Margulies . DEPARTMENT OF BIOENGINEERING, UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA 19104 APStracts 5:0192L, 1998.
• Effects of hypoxia on energy state and ph in resting pulmonary and femoral arterial smooth muscle. Leach, Rm, Dw Sheehan, Vp Chacko and Jt Sylvester. Division of Pulmonary and Critical Care Medicine, Department of Medicine1; and Division of Nuclear Magnetic Resonance, Department of Radiology and Radiological Science2, The Johns Hopkins Medical Institutions, Baltimore, MD 21224 APStracts 5:0193L, 1998.
• The effects of maternal vitamin a status on fetal heart and lung; changes in the expression of key developmental genes. Antipatis, Christos, Cheryl J. Ashworth, George Grant, Richard G. Lea, Susan M. Hay, and William D. Rees. The Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB, Scotland, United Kingdom APStracts 5:0194L, 1998.
• Role of wall tension in hypoxic responses of isolated rat pulmonary arteries. Ozaki, Masami, Carol Marshall, Yoshikiyo Amaki and Bryan E Marshall. 1. Department of Anesthesia, University of Pennsylvania, Philadelphia, PA, 2. Department of Anesthesia, Jikei University School of Medicine, Tokyo, Japan, Performance Site: This work was performed in the Center for Anesthesia Research, Department of Anesthesiology, University of Pennsylvania, Philadelphia, PA, 19104. APStracts 5:0195L, 1998.
• C-amp activation of chloride and fluid secretion across the rabbit alveolar epithelium. Nielsen, Vance G., Michael D. Duvall, Manuel S. Baird, Sadis Matalon,. Departments of Anesthesiology1, Physiology and Biophysics2, and Pediatrics3, The University of Alabama at Birmingham, Birmingham, AL 35233 APStracts 5:0196L, 1998.
• Alveolar macrophage apoptosis and tnf-[alpha], but not p53 expression, correlate with murine response to bleomycin. Ortiz, Luis A., Kryztof Moroz, Jing-Yao Liu, Gary W. Hoyle, Timothy Hammond, Raymond F. Hamilton, Andrij Holian, William Banks, Arnold R. Brody and Mitchell Friedman. (1). Sections of Pulmonary Diseases, Critical Care and Environmental Medicine (1) and Nephrology (3), Department of Medicine, Tulane University Medical Center, New Orleans, Louisiana 70112, (2). Lung Biology Program, Department of Pathology, Tulane University Medical Center, New Orleans, Louisiana 70112, (4). Division of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Texas Medical School, Houston, Texas 77030, (5). Division of Geriatrics, Saint Louis University, 1402 S. Grand Blvd, Saint Louis, Missouri 63104 APStracts 5:0197L, 1998.