APStracts (ISSN 1080-4757) Vol. 5, 1998

The American Physiological Society

• Cytosolic ph regulates gcl through control of phosphorylation states of cftr. Kopito, M. M. Reddy; Ron R., and P. M. Quinton. University of California, San Diego, School of Medicine, Department of Pediatrics-0831, La Jolla, CA 92093-0831, Department of Biology, Stanford University, Palo Alto, CA 94305 APStracts 5:0201C, 1998.
• Identification of the ph sensor and activation by chemical modification of the clc-2g cl- channel. Stroffekova, Katarina, Elena Y. Kupert, Danuta H. Malinowska and John Cuppoletti,. 1Department of Molecular and Cellular Physiology and 2Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0576. APStracts 5:0202C, 1998.
• Focus: exocytosis is not involved in the activation of chloride secretion via cftr in calu-3 epithelial cells.. Guggino, William B. Department of Physiology and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205. APStracts 5:0203C, 1998.
• Amino acid effects on the translational repressor 4e-bp1 are mediated primarily by l-leucine in isolated adipocytes. Fox, Heather L., Phuong T. Pham, Scot R. Kimball, Leonard S. Jefferson, and Christopher J. Lynch_. Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033 APStracts 5:0204C, 1998.
• Effects of cgmp and sodium nitroprusside on odor responses in turtle olfactory sensory neurons. Inamura, Kouhei, Makoto Kashiwayanagi, and Kenzo Kurihara. Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060, Japan APStracts 5:0205C, 1998.
• Mechanical stretch activates heparin-binding egf-like growth factor expression in bladder smooth muscle cells by autocrine release of angiotensin ii. Park, John M., Joseph G. Borer, Michael R. Freeman, Craig A. Peters. Urologic Laboratory, Department of Urology, Children's Hospital and Harvard Medical School, Boston, MA APStracts 5:0206C, 1998.
• Regulation of angiotensin ii-induced jak2 tyrosine phosphorylation. roles of shp-1 and shp-2. Marrero, Mario B., Virginia J. Venema, Hong Ju, Douglas C. Eaton and Richard C. Venema,. 1Vascular Biology Center, 2Department of Pharmacology and Toxicology, and 4Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912 and 3Center for Cell and Molecular Signaling, Emory University School of Medicine, Atlanta, GA 30322 APStracts 5:0207C, 1998.
• Molecular dissection of a positive c-terminus domain of cx32 that inhibits gap junction gating sensitivity. Wang, Xiao Guang, and Camillo Peracchia. Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642-8711 APStracts 5:0208C, 1998.
• Differentiation of the caco-2 intestinal cell line is associated with g1 arrest and suppression of cdk2 and cdk4 activities. Ding, Qing-Ming, Tien C. Ko, and B. Mark Evers. Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555, Visiting Scientist from the Institute of Radiation Medicine, Beijing, Peoples Republic of China APStracts 5:0209C, 1998.
• Human calcitonin receptor is directly targeted to and retained in the basolateral surface of mdck cells. Nussenzveig, Daniel R., Maria De Fatima C. Matos, and Colette N. Thaw. Division of Molecular Medicine, Department of Medicine, Cornell University Medical College, New York, N.Y., 10021. APStracts 5:0210C, 1998.
• Regulation of cytoskeletal mechanics and cell growth by myosin light chain phosphorylation. Cai, Shuang, Lidija Pestic-Dragovich, Martha E. O_donnell, Ning Wang, Donald Ingber, Elliot Elson and Primal De Lanerolle. 1Physiology and Biophysics. University of Illinois at Chicago, 2Human Physiology, University of California, Davis, 3Physiology, School of Public Health, Harvard University, 4Children_s Hospital and Harvard Medical School and 5Biophysics and Molecular Biophysics, Washington University Medical School, St. Louis APStracts 5:0211C, 1998.
• Luminal l-alanine stimulates exocytosis at the k+-conductive apical membrane of aplysia enterocytes. Boahene, Jerod Denton Derek, and William M. Moran. Department of Biology, University of Central Arkansas, Conway, AR 72035-0001, 1Department of Physiology, Dartmouth Medical School, Hanover, NH 03755. 2Meharry Medical College, Nashville, TN 37204 APStracts 5:0212C, 1998.
• Analysis of a ca2+-activated k+ channel that mediates hyperpolarization via the g protein-coupled thrombin receptor pathway.. Sullivan, Richard, Suneil K. Koliwad, and Diana L. Kunze. Research Service, Houston VA Medical Center, and the Departments of Medicine and of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030. APStracts 5:0213C, 1998.
• Sphingosylphosphorylcholine stimulates mitogen-activated protein kinase via a ca2+-dependent pathway. Chin, Ting-Yu, and Sheau-Huei Chueh_. Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan APStracts 5:0214C, 1998.
• The ap-1 clathrin adaptor on tubulovesicles of gastric acid secretory (oxyntic) cells contains an immunologically distinct b -adaptin. Okamoto, Curtis T., and Young Y. Jeng. Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033 APStracts 5:0215C, 1998.
• Human cytomegalovirus infection nearly abolishes na,k,cl cotransporter expression and function in mrc-5 fibroblasts. Maglova, Lilia M., William E. Crowe, Peter R. Smith, An[acute]ibal A. Altamirano# and John M. Russell. Department of Physiology, Allegheny University of the Health Sciences, 2900 Queen Lane, Philadelphia, PA 19129 and #Instituto de Investigaciones Cardiol[acute]ogicas, Facultad de Medicina, Universidad de Buenos Aires, Marcelo T. deAlvear 2270, 1122 Buenos Aires, Argentina APStracts 5:0216C, 1998.
• Bioluminescent detection of atp release mechanisms in epithelia. Taylor, Amanda L., Brian A. Kudlow, Kevin L. Marrs, Dieter C. Gruenert, William B. Guggino and Erik M. Schwiebert. 1Department of Physiology and Biophysics, Department of Cell Biology, and Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, BHSB 740, 1918 University Blvd., Birmingham, AL 35294-0005, 2Departments of Physiology and Pediatrics, Johns Hopkins University School of Medicine, Johns Hopkins Cystic Fibrosis Research Center, Physiology 202, 725 North Wolfe Street, Baltimore, MD 21205, 3Department of Laboratory Medicine, Cardiovascular Research Institute, University of California at San Francisco, SU203, Box 0911, San Francisco, CA 94143-0911 APStracts 5:0217C, 1998.
• Hydrogen peroxide inhibits camp-induced cl- secretion across colonic epithelial cells. Duvall(, Michael D., ), Yi Guo() and Sadis Matalon(,). Department of Anesthesiology(1), Physiology and Biophysics(2) and Pediatrics(3), University of Alabama at Birmingham, Birmingham, AL 34294 APStracts 5:0218C, 1998.
• Membrane lipid diffusion and band 3 protein changes in human erythrocytes due to acute hypobaric hypoxia. Celed_n, Gloria, Gustavo Gonz_lez, Carlos P. Sotomayor and Claus Behn. 1 Departamento de Fisiolog_a, Facultad de Ciencias, Universidad de Valpara_so., 2 Instituto de Qu_mica, Facultad de Ciencias B[beta]sicas y Matem[beta]ticas, Universidad Cat_lica de Valpara_so., 3 Departamento de Fisiolog_a y Biof_sica, Facultad de Medicina, Universidad de Chile. APStracts 5:0219C, 1998.
• Mechanism and regulation of biotin uptake by the human colonic epithelial cell line ncm460: a na+ dependent, carrier-mediated process that is shared with pantothenic acid. Said, Hamid M., Alvaro Ortiz, Eric McCloud, David Dyer, Mary Pat Moyer, and Stanley Rubin. VA Medical Center, Long Beach, CA 90822; University of California School of Medicine, Irvine, CA 92717; University of Texas Health Science Center, San Antonio, TX 78284, INCELL Corporation, San Antonio, TX 78288 and VA Medica_ Center, Sepulveda, CA 91343 APStracts 5:0220C, 1998.
• Antisense oligonucleotide to pkc-[epsilon] alters camp-dependent stimulation of cftr in calu-3 cells. Liedtke, Carole M., and Thomas S. Cole. The Cystic Fibrosis Center and Departments of Pediatrics and Physiology & Biophysics, Case Western Reserve University, Cleveland, OH 44106 APStracts 5:0221C, 1998.
• Functional characterization of alternatively spliced human serca3 transcripts. Poch, Esteban, Stephen Leach, Susan Snape, Tasha Cacic, David H. Maclennan and Jonathan Lytton,. 1Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada, T2N 4N1, the 2Banting and Best Department for Medical Research, University of Toronto, Toronto, ON, Canada M5G 1L6, and the 3Renal Division, Departments of Medicine, Brigham and Women_s Hospital and Harvard Medical School, Boston, MA 02115 APStracts 5:0222C, 1998.
• Atp-dependent regulation of inwardly rectifying k+ current in bovine retinal pigment epithelial cells. Hughes, Bret A., and Masayuki Takahira. Departments of Ophthalmology and Physiology, University of Michigan, Ann Arbor, MI 48105 APStracts 5:0223C, 1998.
• Effect of serum and mechanical stretch on skeletal a-actin gene regulation in cultured primary muscle cells. Carson, James A., and Frank W. Booth. Department of Integrative Biology, Pharmacology and Physiology, The University of Texas Health Science Center, Houston, Texas, 77030 APStracts 5:0224C, 1998.
• Calcium depolarizes adrenal cortical cells through selective inhibition of an atp-activated potassium current. Gomora, Juan Carlos, and John J. Enyeart. 1Department of Pharmacology, The Ohio State University, College of Medicine, Columbus, OH 43210-1239, 2The Neuroscience Program, The Ohio State University, College of Medicine, Columbus, OH 43210 -1239 APStracts 5:0225C, 1998.
• Selective hydrolysis of plasmalogens in endothelial cells following thrombin stimulation. Creer, Michael H., and Jane McHowat. Department of Pathology, St. Louis University School of Medicine, St. Louis, MO 63104 APStracts 5:0226C, 1998.
• Characterization of cftr expression and chloride channel activity in human endothelia. Tousson, Albert, Brian A. Van Tine, Anjaparavanda P. Naren, George M. Shaw, and Lisa M. Schwiebert, . The Gregory Fleming James Cystic Fibrosis Research Center1 and the Departments of Cell Biology2, Pathology3, Medicine4, and Physiology and Biophysics5 and the Howard Hughes Medical Institute6, University of Alabama at Birmingham, Birmingham, AL 35294 APStracts 5:0227C, 1998.
• Detection of local atp release from activated platelets using cell surface-attached firefly luciferase.. Beigi, Reza, Eiry Kobatake, Masuo Aizawa and George R. Dubyak. 1Department of Physiology and Biophysics, Case Western Reserve University, Cleveland OH 44106-4970; and 2Department of Bioengineering, Tokyo Institute of Technology, 4259, Nagatsuta, Midori-ku, Yokohama 226-8501, Japan. APStracts 5:0228C, 1998.
• Cell-cell contact between adult rat cardiac myocytes regulates kv1. 5 and kv4.2 k+ channel mrna expression. Hershman, Kenneth M., and Edwin S. Levitan. Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261 APStracts 5:0229C, 1998.
• Adrenergic stimulation of na+ transport across cultured adult rat alveolar epithelial cells involves activation of an apical cl- channel with properties similar to cftr. Jiang, Xinpo, David H. Ingbar, and Scott M. O_grady. Departments of Physiology and Medicine, University of Minnesota, Minneapolis, MN 55455 APStracts 5:0230C, 1998.
• Blockade by cyclic amp of native sodium channels of adult rat skeletal muscle fibers. Desaphy, Jean-Fran[cedilla]cois, Annamaria De Luca, Diana Conte Camerino. Prof. Diana Conte Camerino, Unit[grave]a di Farmacologia, Dipartimento Farmaco-Biologico, Facolt[grave]a di Farmacia, Universit[grave]a degli Studi di Bari, via Orabona 4, I-70125 Bari, Italia, Tel. and fax: (39) 80-544-28-01, E-mail: conte@farmbiol.uniba.it APStracts 5:0231C, 1998.
• Lc-pk1 cells express the renal high-affinity h+/peptide cotransporter: its kinetic characterization and role as an acid loader. Wenzel, Uwe, Daniela Diehl, Martina Herget, and Hannelore. Daniel. Institute of Nutritional Sciences, University of Giessen, Wilhelmstra[beta]e 20, 35392 Giessen, FRG. APStracts 5:0232C, 1998.
• Functional demonstration of na-k-2cl cotransporter activity in isolated, polarized choroid plexus cells. Wu, Qiang, Eric Delpire, Steven C. Hebert and Kevin Strange,. Laboratory of Cellular and Molecular Physiology, Departments of 1Anesthesiology and 2Pharmacology, 3Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 APStracts 5:0233C, 1998.
• Expression of twik-1, a novel weakly inward rectifying potassium channel in rat kidney Cluzeaud, F., R. Reyes, B. Escoubet, M. Fay, M. Lazdunski, J. P Bonvalet, F. Lesageand N. Farman. INSERM U478 and *U426, Facult[umlaut]a de M[umlaut]adecine X. Bichat, BP 416, F-75870 Paris cedex 18, France,**Institut de Pharmacologie Mol[umlaut]aculaire et Cellulaire, CNRS 600, Route des Lucioles, Sophia Antipolis 06560 Valbonne, France. APStracts 5:0234C, 1998.
• Cytoskeletal-integrin interactions are required for fluid shear -induced mechanical signaling in mc3t3-e1 osteoblasts. Pavalko, Fredrick M., Neal X. Chen, Charles H. Turner, David B. Burr, Simon Atkinson, Yeou-Fang Hsieh, Jinya Qiu and Randall L. Duncan,. Department of Physiology and Biophysics1, Department of Anatomy2, Department of Orthopaedic Surgery3, and Division of Nephrology, University School of Medicine, Indianapolis, IN 46202 APStracts 5:0235C, 1998.
• Neuropeptide regulation of human dermal microvascular endothelial cell icam-1 expression and function. Quinlan, Kimberly L., In-Sung Song, Nigel W. Bunnett, Eleanor Letran, Martin Steinhoff, Brad Harten, John E. Olerud, Cheryl A. Armstrong, S. Wright Caughman and John C. Ansel,. 1 Department of Dermatology and Emory Skin Diseases Research Core Center, Emory University School of Medicine, Atlanta, GA, 30322; Departments of Physiology and Surgery, University of California San Francisco, San Francisco, CA, 94140; 3 Department of Dermatology, University of Washington, Seattle, WA, 98195; and 4 VA Medical Center, Atlanta, GA, 30322 APStracts 5:0236C, 1998.
• Gap junction permeability is diminished in proliferating vascular smooth muscle cells. Kurjiaka, David T., Timothy D. Steele, Mary V. Olsen, and Janis M. Burt . Department of Physiology, University of Arizona, Tucson, Arizona 85724 APStracts 5:0237C, 1998.
• Human monocyte stimulus-coupled il-1b posttranslational processing: modulation via monovalent cations. Perregaux, David G., and Christopher A. Gabel. Pfizer Central Research, Groton, CT 06340 APStracts 5:0238C, 1998.
• Dietary zinc deficiency decreases plasma level and hepatic mrna abundance of apolipoprotein a-i in rats and hamsters*. Wu, John Y. J., Scott K. Reaves, Yi Ran Wang, Yan Wu, Polin P. Lei, and Kai Y. Lei. Department of Nutritional Sciences, University of Arizona APStracts 5:0239C, 1998.
• Activation of the jak/stat pathway by reactive oxygen intermediates. Simon, Amy R., Usha Rai, Barry L. Fanburg and Brent H. Cochran. 1Pulmonary and Critical Care Division, Tupper Research Insititute, New England Medical Center. Boston, MA 02111 and 2Department of Physiology, Tufts University School of Medicine, Boston, MA 02111 APStracts 5:0240C, 1998.
• Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice. Yang, Baoxue, Hans G. Folkesson, Jian Yang, Michael Matthay, Tonghui Ma, and A. S. Verkman. Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, CA, 94143-0521, and Department of Animal Physiology, Lund University, Lund, Sweden. APStracts 5:0241C, 1998.
• K-cl cotransporter expression in the human kidney. Nag, Helen Liapis M., and Deepak M. Kaji. 1Department of Pathology, Washington University School of Medicine, St. Louis, MO; and 2Nephrology Section, Department of Medicine, V.A. Medical Center, Bronx, New York, 10468 and Mount Sinai School of Medicine, New York, NY 10029 APStracts 5:0242C, 1998.
• G protein-dependent activation of smooth muscle enos mediated by the natriuretic peptide clearance receptor (npr-c). Murthy, K. S., J-G. Jin, B. Q. Teng, and G. M. Makhlouf. Departments of Physiology and Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 -0711 APStracts 5:0243C, 1998.
• Effect of pcmbs on the co2 permeability of xenopus oocytes expressing aquaporin 1 or its c189s mutant Cooper, Gordon J., Walter F. Boron. Dept of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar St, New Haven, CT065109, USA APStracts 5:0244C, 1998.
• The rapid stimulation of glucose transport by mitochondrial uncoupling depends in part on cytosolic ca2+ and ca2+-sensitive protein kinase c. Khayat, Zayna A., Theodoros Tsakiridis, Atsunori Ueyama, Romel Somwar, Yousuke Ebina and Amira Klip,. 1Programme in Cell Biology, The Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada, 2Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada, 3Current address: Department of Medicine, University of Toronto, Toronto, ON, M5S 1A8, Canada, 4Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan APStracts 5:0245C, 1998.
• Contraction-induced injury to single muscle fibers: velocity of stretch does not influence the force deficit. Lynch, Gordon S., and John A. Faulkner,. Institute of Gerontology1 and Departments of Physiology2 and Biomedical Engineering3, The University of Michigan, Ann Arbor, MI 48109-2007 APStracts 5:0246C, 1998.
• Colocalization of glycolytic enzyme activity and katp channels in basolateral membrane of necturus enterocytes. Dubinsky, William P., O. Mayorga-Wark, and Stanley G. Schultz. Department of Integrative Biology, Pharmacology and Physiology, University of Texas Medical School, P.P. Box 20708, Houston, Texas 77225, Tel: (713)500-6307, Fax:(713)500-6305, email:sschultz@girch1.med.uth.tmc.edu APStracts 5:0247C, 1998.
• Thyroid hormone modifies mitochondrial phenotype by increasing protein import without altering protein degradation. Craig, Elaine E., Alan Chesley, and David A. Hood. Departments of Biology and Kinesiology and Health Sciences, York University, North York, Ontario, Canada, M3J 1P3 APStracts 5:0248C, 1998.
• Nitric oxide relaxes human myometrium by a cyclic gmp-independent mechanism. Kuenzli, Karri A., Iain L. O. Buxton, James E. Barber, Terrence McGaw and Michael E. Bradley,. Departments of Pharmacology1, and Obstetrics and Gynecology2, University of Nevada, Reno, Reno, NV 89557, Department of Physiology and Cell Biology, MS 352, University of Nevada, Reno, Reno, NV 89557 -0046 APStracts 5:0249C, 1998.
• Relationship between [125i]rti-55-labeled cocaine binding sites and the serotonin transporter in rat placenta. Shearman, Lauren P., Alison M. McReynolds, Feng C. Zhou and Jerrold S. Meyer. 1Department of Psychology, Neuroscience and Behavior Program, University of Massachusetts, Amherst, MA 01003 U.S.A. and 2Department of Anatomy, Indiana University School of Medicine, Indianapolis, IN 46202 U.S.A. APStracts 5:0250C, 1998.
• Taxol inhibits cytoplasmic dynein-driven vesicular traffic from endosomes to lysosomes in cv-1 cells. Sonee, Manisha, Ernesto Barr(n, Francie A. Yarber and Sarah F. Hamm -Alvarez. 1Department of Pharmaceutical Sciences and 2Electron Microscopy Core Facility, Doheny Eye Institute, University of Southern California, Los Angeles CA APStracts 5:0251C, 1998.
• Squalamine, a novel cationic steroid, specifically inhibits the brush border na+/h+ exchanger isoform, nhe3. Akhter, S., S. K. Nath, C. M. Tse, J. Williams+, M. Zasloff+ and M. Donowitz. Departments of Medicine and Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 And +Magainin Pharmaceuticals Inc., Plymouth Meeting, PA 19642 APStracts 5:0252C, 1998.